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BUTISOL SODIUM® (butabarbital sodium tablets, USP and butabarbital sodium oral Option, USP) would be the sodium salt of the weak acid. Barbiturates are weak acids which have been absorbed and rapidly distributed to all tissues and fluids with significant concentrations during the Mind, liver, and kidneys.

butabarbital will increase effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers may enhance metabolism of ifosfamide to its metabolite. Check for greater outcomes/toxicities if combined with CYP2B6 inducers.

Documentation of allergenic cross-reactivity for barbiturates is limited. On the other hand, thanks to similarities in chemical composition and/or pharmacologic steps, the potential of cross-sensitivity cannot be ruled out with certainty.

butabarbital will lessen the extent or impact of zolpidem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.

Watch Intently (one)butabarbital will lower the level or outcome of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

butabarbital will reduce the level or impact of bosentan by impacting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unknown.

butabarbital will lessen the level or impact of fesoterodine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

Barbiturates could potentially cause fetal problems when administered to some pregnant woman. Retrospective, situation-managed experiments have proposed a link in between the maternal use of barbiturates and a better than anticipated incidence of fetal abnormalities.

butabarbital will decrease the extent or influence of ritonavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

The subsequent adverse drug reactions and incidences are derived from product labeling Except if usually specified.

butabarbital will lower the level or effect of cinacalcet by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

butabarbital will lower the level or result of galantamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.

butabarbital will lessen the level or impact of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. For clients with ED, monitor reaction thoroughly on account of probable for lowered performance

Barbiturates look to reinforce the metabolism of exogenous corticosteroids in all probability through the induction of hepatic microsomal enzymes. Individuals stabilized on corticosteroid therapy may possibly call for more info dosage adjustments if barbiturates are included to or withdrawn from their dosage routine.